The monitoring activity carried out by the CRAs in clinical trials, is often one of the activities capable of draining most of the financial resources available and that also take more time. The necessity of phase I no profit studies, is typically to make very high monitoring percentages, with very limited budgets. It is in this context that Promeditec has developed and supplied the Virtual On Site Monitoring service. This activity is carried out with the use of technological peripherals and specific software, enabling most part of the monitoring in remote mode, without the need to move the monitor. The solution has been considered efficient and maximised thanks to the flexibility of the connection that enables the work not to be concentrated all in one day, but dividing it into various parts, meeting the needs of Data Managers in the centres involved. The reduced cost and the predisposition of checklists, specific templates reports compatible with online modalities, have contributed to answering, at best, to the needs presented by the coordinators of the study, making it become an instrument of integration of low cost monitoring also thanks to its easier ability to highlight eventual criticisms in carrying out the clinical study.